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Diabetic Guide to Everything Insulin

What is Insulin: Appreciating the Diabetes Hormone Fundamentals

Table of Contents

What is insulin, and How does it Work?

What is Insulin? Insulin is a hormone responsible for regulating blood sugar levels in the body. It is produced in the pancreas and released into the bloodstream to aid glucose (or blood sugar) in entering the cells to generate energy.

A rise in blood sugar levels triggers insulin secretion. Insulin secretion is also triggered when the pancreas detects sugar transport across the bloodstream. Insulin secretion usually occurs during and after digestion and when blood sugar needs to be regulated. Insulin then attaches to cell surface receptors, most notably in muscle, fat, and liver cells. This binding process promotes glucose uptake from the blood into the cells, lowering overall blood sugar levels. It also aids in the prevention of excessive glucose accumulation in the blood, which can be hazardous.

After sugar enters the cells and is converted into energy, insulin secretion decreases. Thus, insulin production is highly dependent on food intake and digestion and is produced in amounts needed to balance the sugar in the blood.

A Summary of Insulin Balancing

Too little insulin promotes high blood sugar levels, leaving the cells with little or no sugar to convert into energy. Low insulin secretion causes fatigue and weight loss. On the other hand, too much insulin will lead to low blood sugar levels, which is also called hypoglycemia. Hypoglycemia initiates a response from the body to utilize stored glucose and other responses by the nervous system, which can cause dizziness, palpitations, hunger, and anxiety. This balance is essential to bodily processes.

An imbalance of blood sugar levels and insulin production could signify insulin resistance. Therefore, if you are taking insulin medication, you should consult your doctor about your prescribed insulin medication.

The equilibrium of insulin and blood glucose becomes altered in diabetics. The immune system incorrectly assaults and destroys insulin-producing beta cells in the pancreas in type 1 diabetes, resulting in a shortage of insulin production. As a result, persons with type 1 diabetes must use insulin injections to keep their blood sugar levels under control.

Type 2 diabetes, on the other hand, is characterized by insulin resistance, in which the cells of the body become less receptive to the action of insulin. As a result of the cells’ inability to take in enough glucose for energy, blood glucose levels rise. The pancreas may also generate less insulin over time, worsening the situation.

How does insulin function?
The pancreas produces insulin into the bloodstream when blood sugar levels rise after eating. Insulin then attaches to cell surface receptors, most notably in muscle, fat, and liver cells. This binding process promotes glucose uptake from the blood into the cells, lowering overall blood sugar levels. It also aids in the prevention of excessive glucose accumulation in the blood, which can be hazardous.

what is insulin

Insulin Medication and Manufactured Insulin

What is insulin? In the 1920s, doctors administered animal insulin extracted from cows or pigs. Nevertheless, the rise of technology and biological innovations led to the synthetic manufacturing of insulin through bacteria and yeast.

The gene code for amino acids for the insulin protein is inserted into bacteria to allow them to grow and reproduce. The insulin is then extracted or purified and packaged into pens, pumps, or bottles that we can now purchase and consume.

Types of Insulin

Depending on your type of diabetes, there are different types of insulin that your doctor can prescribe you. These types of insulin differ according to the speed of onset, duration of insulin in the body, duration of insulin until its peak, and method of consumption.

Types of Insulin are:

  • Rapid-acting Insulin: quick onset, takes effect about 15 minutes after injection, peaks after 30 minutes, and lasts about 2 to 4 hours. Check out our wide selection of rapid-acting insulin:
  • Short-acting Insulin: takes effect 30 minutes after injection, peaks after 2 hours, and lasts about 3 to 6 hours. Buy our short-acting insulin today.
  • Intermediate-acting Insulin: the onset is between 2 and 4 hours and lasts for 12 to 18 hours. Best for overnight use. See our selection of intermediate-acting insulin:
  • Long-acting Insulin: the onset is about 2 hours and lasts up to 24 hours with no pronounced peak. Buy long-acting insulin.
  • Combination or premixed Insulin: a combination of the different types of insulin mentioned above, so there is no need to administer insulin from multiple bottles. varying onset, peak, and duration depending on the combination or pre-mixing. Check out our premixed insulin.

The specific type of insulin, as well as the dosage, varies for different diabetics. Hence, it is advisable to consult and follow your doctor’s prescriptions when taking insulin medications.

what is insulin

What is Insulin – FAQs

What is Insulin and its significance?
Insulin is necessary for the body to maintain normal blood sugar levels. It enables cells to effectively utilize glucose, which supplies the energy required for many biological tasks. Balanced blood sugar levels are critical for overall health since chronically high blood sugar (hyperglycemia) can lead to diabetes and other issues, whereas hypoglycemia can cause dizziness, confusion, and even unconsciousness.

How is insulin delivered?
Insulin is usually administered subcutaneously either an insulin syringe, insulin pen, or insulin pump. It can also be supplied by an insulin jet injector or an insulin inhaler in some situations, though these methods are less popular.

Who requires insulin therapy?
Insulin therapy may be required for people with diabetes if their bodies do not create enough insulin (Type 1 diabetes) or if their cells do not respond effectively to insulin (Type 2 diabetes). Insulin therapy is intended to help manage blood sugar levels and prevent diabetes complications.

Are there any insulin side effects?
Low blood sugar (hypoglycemia), weight gain, and localized injection site reactions (such as redness or swelling) are also common insulin side effects. Individuals who use insulin must constantly monitor their blood sugar levels and work closely with their healthcare providers to alter their insulin doses as needed.What is Insulin – Summary

Maintaining an insulin-to-blood-glucose balance is critical for diabetes management. Diabetes patients must regularly check their blood sugar levels and, if necessary, give insulin or take medicines to assist control their glucose levels. A healthy diet, regular physical activity, and weight control are also important in increasing insulin sensitivity and improving blood sugar control.

Individuals with diabetes can achieve better insulin balance, avoid complications, and live a healthier and more happy life by working closely with healthcare experts and taking a proactive approach to diabetes management.

Treating extreme Hypgycemia

In situations of severe hypoglycemia (low blood sugar), a glucagon emergency kit is a life-saving aid for diabetics. It contains glucagon, a hormone that helps raise blood sugar levels rapidly.

Here I have summarized and tried to link each medicine brand with its category:

STIMULATORS OF INSULIN RELEASE (Insulin Secretagogues) – increase insulin secretion from the pancreas1
SULFONYLUREAS (SFUs)

Tolbutamide  Orinase®
Glimepiride  Amaryl®
Glipizide  Glucotrol®, Glucotrol XL®
Glyburide 
Micronase®, DiaBeta®
Glyburide, micronized  Glynase PresTab®
GLINIDES
Repaglinide  Prandin®
Nateglinide  Starlix®

EUGLYCEMICS: Medicines that restore blood glucose levels to normal. These medications should not result in hypoglycemia.3 BIGUANIDES: reduces glucose release from the liver; reduces glucose absorption in the intestine; enhances insulin sensitivity (increases glucose uptake and utilization)
Metformin

ALPHA-GLUCOSIDASE INHIBITORS: STARCH BLOCKERS – delay carbohydrate digestion and absorption

THIAZOLIDINEDIONES (Glitazones or TZDs): lower insulin resistance in the body (muscle and fat tissue)

GLP-1 ANALOGS: Increase insulin secretion, decrease glucose release from the liver after meals, prolong stomach emptying, and improve satiety.

DPP-4 INHIBITORS: After meals, enhance insulin secretion and decrease glucose release from the liver.

SGLT2 inhibitors: Increase the amount of glucose excreted in the urine.

COMBINATION ORAL PILLS

Ranibizumab: is a VEGF-A antagonist and recombinant humanized monoclonal antibody used to treat macular edema following retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Metformin: Glucophage®
Extended release (ER): Glucophage XR®, Fortamet®, Glumetza Riomet® (liquid, 500 mg/5ml)

Acarbose:  Precose®

Pioglitazone (preferred over rosiglitazone)  Actos®
Rosiglitazone  Avandia®

Exenatide   Byetta®
Liraglutide Victoza®, Saxenda®, Xultophy®
Albiglutide  Tanzeum®
Dulaglutide  Trulicity®

Semaglutide Ozempic®, Wegovy®, Rybelsus®

Alogliptin  Nesina®
Sitagliptin  Januvia®
Saxagliptin  Onglyza®, Komboglyze®
Linagliptin  Tradjenta®

Canagliflozin  Invokana®
Dapagliflozin Farxiga®
Empagliflozin  Jardiance®
Bexaglifloxin Brenzavvy™
Ertugliflozin Steglatro®

Alogliptin/Metformin  Kazano®
Alogliptin/Pioglitazone Oseni®
Empagliflozin/Linagliptin  Glyxambi®
Empagliflozin/Metformin  Synjardy®
Canagliflozin/Metformin  Invokamet®
Dapagliflozin/Metformin XR  Xigduo XR®
Glyburide/Metformin  Glucovance®
Glipizide/Metformin  Metaglip®
Linagliptin/Metformin Jentadueto®
Rosiglitazone/Metformin Avandamet®
Pioglitazone/Metformin  ActoPlus Met®
Pioglitazone/Glimepiride Duetact®
Rosiglitazone/Glimepiride  Avandryl®
Sitagliptin/Metformin  Janumet®, Janumet-30,
Sitagliptin/Metformin  Janumet XR®
Repaglinide/Metformin  PrandiMet®
Pioglitazone/Metformin XR  ActoPlus Met XR®
Saxagliptin/Metformin XR  Kombiglyze XR®

Byooviz
1 Ranivisio
Cimerli
Lucentis

What is Insulin – Summary

Maintaining an insulin-to-blood-glucose balance is critical for diabetes management. Diabetes patients must regularly check their blood sugar levels and, if necessary, give insulin or take medicines to assist control their glucose levels. A healthy diet, regular physical activity, and weight control are also important in increasing insulin sensitivity and improving blood sugar control.

Individuals with diabetes can achieve better insulin balance, avoid complications, and live a healthier and more happy life by working closely with healthcare experts and taking a proactive approach to diabetes management.

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