About Lucentis Prefilled Syringe
(See detailed Medicine Prescription Information here)
Type of medication – (Monoclonal Antibody – cloning technique used to create unique white blood cell) injection.
Type – Prescription medication.
Used for – treatment of patients with wet age-related macular degeneration (WAMD), diabetic retinopathy (DR), diabetic macular edema (DME), myopic choroidal Neovascularization (mCNV), and macular edema following retinal vein occlusion (RVO).
Medicine family – (Monoclonal Antibody – cloning technique used to create unique white blood cells.
Dosage – For ophthalmic intravitreal injection only
Lucentis Prefilled Syringe is a prescription medicine for the treatment of patients with:
- wet age-related macular degeneration (WAMD)
- diabetic retinopathy (DR)
- diabetic macular edema (DME)
- myopic choroidal Neovascularization (mCNV)
- macular edema following retinal vein occlusion (RVO)
Ranibizumab is branded as Lucentis and is a monoclonal antibody fragment (Fab). It is created from the same parent mouse antibody as bevacizumab. Genentech develops Ranibizumab which Novartis markets. A study has indicated that usage of Lucentis is associated with a lower risk of intestinal stomach problems and a low rate of eye-related side effects. Clinical trials’ most common side effects were conjunctival hemorrhage, eye pain, vitreous floaters, increased intraocular pressure, and intraocular inflammation.
Know more about some terms:
- AMD or ARMD (Age-related Macular Degeneration) – The condition in which a person will have blurred or no vision in the center of the visual field. It may not result in complete blindness but will make regular life difficult.
- Macular Edema – This may result in yellow deposits in and under the eye’s macula. The retina may thicken (edema), affecting central vision.
- Branch Retinal Vein Occlusion – Is observed in the elderly and is caused by the occlusion of one of the branches of the central retinal vein.
Dosage:
It will depend on the essential treatment the medicine is used for:
- For Neovascular (Wet) Age-Related Macular Degeneration (AMD):
- LUCENTIS 0.5 mg (0.05 mL) as an intravitreal injection once a month (approximately 28 days).
- Alternate dosage is not as effective
- Start with 3 monthly doses followed by less frequent dosing with regular assessment.
- Start with one dose every 3 months after 4 monthly doses with periodic evaluations.
- Macular Edema following Retinal Vein Occlusion (RVO):
- LUCENTIS 0.5 mg (0.05 mL) as an intravitreal injection once a month (approximately 28 days).
- Diabetic Macular Edema (DME) and Diabetic Retinopathy (DR):
- LUCENTIS 0.3 mg (0.05 mL) as an intravitreal injection once a month (approximately 28 days).
- Myopic Choroidal Neovascularization (mCNV)
- LUCENTIS 0.5 mg (0.05 mL) as an intravitreal injection once a month (about 28 days) for up to three months.
Separately packaged as a single-use Lucentis Prefilled Syringe and for single eyes are designed to provide 0.05 mL for intravitreal injections:
- 10 mg/mL solution (LUCENTIS 0.5 mg)
- 6 mg/mL solution (LUCENTIS 0.3 mg)
Separately packaged as a single-use glass vial designed to provide 0.05 mL for intravitreal injections:
- 10 mg/mL solution (LUCENTIS 0.5 mg)
- 6 mg/mL solution (LUCENTIS 0.3 mg)
Warnings – Lucentis Prefilled Syringe
- Monitor patients regularly following injections.
- Endophthalmitis and retinal detachments may occur.
- May observe increases in intraocular pressure (IOP) during the pre-intravitreal and post-intravitreal injections.
- May pose the risk of arterial thromboembolic events.
- Higher risk of fatalities in patients with DME and DR at baseline were treated monthly with LUCENTIS compared with control.
- Other risks are conjunctival hemorrhage, eye pain, vitreous floaters, and increased IOP.
Storage – Lucentis Prefilled Syringe
Store LUCENTIS in refrigerator at 2º-8ºC (36º-46ºF). DO NOT FREEZE. Always read the label and expiry date. Protect LUCENTIS from light and leave it in the original package under sealed condition until the time of use. Do not Freeze Lucentis.
Precautions:
- Do not share Lucentis prefilled syringe or vial with other people
- Do not re-use needles
- Visit your doctor regularly.
- Always read the label and expiry date.
- Only use the product if the packaging is protected.
- Protect LUCENTIS from light and leave it in the original package under sealed condition until the time of use.
- Do not Freeze Lucentis Prefilled Syringe.
- Keep Lucentis Prefilled Syringe and associated medicines out of the reach of children.
